October 09, 2014

 

On September 29, a Ugandan man, about 30 years old and presenting symptoms of hemorrhagic fever, died in a hospital in the Ugandan capital, Kampala. On October 4, the Centers for Disease Control and Prevention (CDC) announced that the man's blood tests had revealed Marburg fever. MSF, which has been working in Uganda since 1986, is currently mobilizing its teams in preparation for a response.

Marburg hemorrhagic fever is an acute infectious viral disease belonging to the same family as Ebola. Unfortunately, it is often fatal. The modes of transmission (contact with certain animals like bats or monkeys, and between people through direct contact with blood; bodily fluids; secretions; and tissue from sick people, animals or dead bodies) and the symptoms (sudden onset of high fever, severe headaches, general pain and weakness, vomiting, diarrhea, internal and external bleeding) are very similar to those of Ebola. During the incubation period (2 to 21 days), infected people are not contagious.

“As with Ebola, there’s no vaccine and no treatment other than supportive care (rehydration, stabilizing blood pressure, reducing the fever, [and] administering pain killers and antiemetics),” explains Dr. Estrella Lasry, MSF advisor on tropical diseases. “The last Marburg epidemic in Uganda was in 2012. It lasted just over two months. There were 20 cases and 45 percent of them were fatal.  That same year there were also 2 Ebola epidemics in the country.”

MSF has been working in Uganda since 1986. "Usually, we run HIV and AIDS-related activities," says Pierre Mendihart, MSF program manager in Uganda. "But as in all our projects, our teams are always on stand-by to respond to emergency situations: in 2013/2014, it was assistance to Congolese and South-Sudanese refugees ; in 2012 it was a response to the Ebola epidemics.”

The man who died in September lived near Mpigi, a district situated about 23 miles from Kampala. He was employed in one of the district’s health centers and worked nights at Mengo hospital, in the heart of the capital. “The Ministry of Health and the CDC are currently trying to trace all the people who have been in contact with him and who may have been infected so they can—if necessary—be isolated and placed under surveillance,” explained Pierre Mendihart. “Mpigi and Mengo could be the first places that potentially infected people come to. Personnel need to be properly protected (triage, 'hazmat' suits, gloves, and masks),so they can examine and refer suspected cases in complete safety.”

As with Ebola, the family and health personnel in contact with infected patients are particularly at risk of contracting Marburg. In collaboration with the Ministry of Health, MSF is strengthening its capacity to respond to a potential epidemic, initially focusing its actions on health personnel supervision and training in clinical management of the disease and infection control measures.

An emergency team is being put in place, comprising two coordinators, three medical staff (who have just finished Ebola missions in West Africa) and two technicians specializing in water, hygiene, and sanitation. A stock of specialized equipment was already on site and a full Ebola/Marburg treatment kit for 15 patients is on its way out to Kampala.

MSF will supply "hazmat” suits and personal protective equipment (PPE) as well as specialized hygiene and sanitation equipment to the Mpigi and Mengo health centers. The centers’ staff will be trained in the correct use of PPE and implementing infection control measures. In the referral center at Kampala’s Mulago hospital, where any suspected Marburg cases would be sent, MSF will rehabilitate the treatment unit and support the activities of the Ministry of Health should any patients be admitted. Lastly, an MSF ambulance will transport suspected cases from the health centers to Mulago hospital.

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