Agenda
Session 1: Introduction & Current Field Diagnostics
| Time |
Session |
Presenter |
Goals |
| 8.30 |
Registration, poster mounting, coffee |
|
|
| 8.55 |
Welcome and introduction |
Tido von Schon-Angerer MSF |
|
9.00- 10.35
95mins |
Session 1: TB field diagnostics |
Chairs:
Nathan Ford MSF
Co-chair: TBD |
What we do & can do for Diagnosis and DST
(existing techniques or max 1 year horizon) |
9.00-9.10
10mins |
Optimization of sputum sample quality |
Mishal Khan Pakistan/LSHTM |
The basis for later steps - Is it done well enough,
can/should we improve it, what can we do? |
9.10-9.25
15mins |
Microscopy: Something Old, Something
New... |
Kevin Fennelly, New Jersey Medical School,New Jersey, USA |
Conventional technique & potential for increasing
sensitivity with care/reading duration.
Newer developments: auramine, bleach, FDA, filters.
Adequacy of current policy emphasising smears over
culture. |
9.25-9.45
20mins |
Decontamination & culture : best techniques for different settings |
Carlton Evans Peru/IFHAD |
Review traditional and newer techniques for diagnosis
& DST: TLA, MODS, NRA, colorimetric etc
Perhaps explore cost-effectiveness?
Discussion of missing major validation studies
Start laying foundation for discussion of gaps |
|
9.45-9.55 |
Prize talk 1 |
Jaime Robeldo Columbia |
Is there still a place for conventional methods in the rapid detection of rifampin and isoniazid resistance in M. tuberculosis? The case of thin layer agar direct method |
|
9.55-10.05 |
Prize talk 2 |
Beatriz Herrera Peru |
Optimisation Of Tb Field Testing: In-Transit Sputum Decontamination & Culture On Colorimetric Selective Media For Tb Diagnosis & Drug-Susceptibility Testing |
10.05-10.35
30mins |
Questions & Discussion |
8-person panel of all of above |
How can techniques be better implemented/optimised |
10.35-11.00
25mins |
Coffee and poster viewing |
|
|
Session 2: Operational Challenges for Field Diagnostics
| Time |
Session |
Presenter |
Goals |
11.00-12.40
100mins |
Session 2: Challenges of field diagnosis |
Chairs: Francis Varaine
Paul Van Helden, Stellenbosch
|
How can the techniques introduced above best be
used in the field, in pragmatic daily use? What are the
most appropriate operational applications? What is the
best use of existing tools in this setting?
|
11.00-11.20
20mins |
TB in HIV positive people: Ruling out TB & diagnosing TB & MDRTB |
Helen Ayles Zambia/London |
Difficulty diagnosing TB in HIV positive people.
Difficulty obtaining specimens in HIV positive people
Difficulty ruling-out TB to allow HAART
Inadequacy of clinical algorithms
Importance as barrier to preventive therapy
Mortality from empiric regimes for HIV-MDRTB
co-infection- Choices? Algorithms? Management?-
extrapulmonary |
11.20-11.35
15mins |
The challenge of diagnosing paediatric TB |
Heather Zar UCT |
Choice, challenges, algorithms, PPD...
Difficulty diagnosing & obtaining specimens
Include sputum collection & induced sputum, fineneedle
aspiration, gastric aspiration, stool, string etc.
Maybe include IGRAs & urine tests
Problems with lack of gold standard |
11.35-11.50
15mins |
Diagnostic biosafety : What’s required for what tests? |
Paul Jensen CDC |
How to protect lab staff; what is needed, what is
realistic, what is enough...
Challenge of taking diagnosis closer to the patient.
Infecting staff; cross-contamination between tests
Need for biosafety cabinet & autoclaves |
11.50-12.10
10mins |
Prize talk |
Dirk Mueller LSHTM |
"Estimating the resource need for using culture to diagnose TB" |
12.10-12.40
30mins |
Questions & Discussion |
7-person panel of all of the above |
|
12.40-2.00
80mins |
Lunch and poster viewing |
|
|
Session 3: Future Field Diagnostics
| Time |
Session |
Presenter |
Goals |
|
2.00- 3.00
80mins |
Session 3: Current pipeline and future tests |
Eric Goemaere, MSF
Ruth McNerney LSHTM |
|
|
2.00-2.10
10mins |
Field tests: What, where & why? |
Gilles van Cutsem MSF S Africa |
What do we mean by a field appropriate test? |
|
2.10-2.25
15mins |
Current pipeline for commercial diagnostic tests |
Mark Perkins FIND |
Available now vs. next year vs ‘promising techniques’ |
|
2.25-2.40
15mins |
Current pipeline for non-commercial diagnostic techniques |
Andrew Ramsay TDR/WHO |
Models of provision: commercial kits vs techniques |
|
2.40-3.10
30mins |
Discussion: will the current pipeline produce what patients need? |
Panel including all of the above
+ Anandi Martin, IMT Antwerp
+ Pamela Hepple, Manson Unit MSF
|
Are we satisfied?
Are the field needs being addressed?
Will they be met with current product pipeline?
Commercial vs non-proprietary techniques
Centralised vs point of care
Control and quality control
Try to bring out gaps, again, highlight lack of likely
tools, failure of commercial model, etc |
|
3.10-3.40
30mins |
Coffee and posters |
|
|
Session 4: Encouraging Innovation & Progress in Field Diagnostics
| Time |
Session |
Presenter |
Goals |
3.40- 5.20
100 mins |
Session 4: How to make innovation
happen |
Mark Harrington TAG
Marc Mendelson UCT
|
To discuss the gaps brought up in earlier sessions
and to try propose ways to address them |
3.40- 3.50
10min |
What are the research gaps to be filled? |
Rob Wilkinson UCT/Imperial |
|
3.50- 4.00
10min |
Why aren’t best tests being used? |
Dave Moore Peru/Imperial |
|
4.00- 4.10
10min |
Is there enough money? |
Javid Sayed TAG |
|
4.10- 4.20
10min |
Why are TB diagnostics still so inadequate? |
Martine Usdin MSF |
|
4.20 -5.20
60mins |
Discussion & Questions |
Panel including all of above, plus:
Val Snewin The Wellcome Trust
Denny Mitchison St George’s, London
|
|
5.20-5.25
5mins |
Poster prize for best abstract presented as a poster |
|
|
5.25-5.40
15mins |
Conclusions |
Tido von Schon-Angerer MSF
Carlton Evans Peru/IFHAD |
|
5.40-7.00
80mins |
Reception |
|
|
|
