Agenda

Session 2: Operational Challenges for Field Diagnostics

Time	Session	Presenter	Goals
11.00-12.40 100mins	Session 2: Challenges of field diagnosis	Chairs: Francis Varaine Paul Van Helden, Stellenbosch	How can the techniques introduced above best be used in the field, in pragmatic daily use? What are the most appropriate operational applications? What is the best use of existing tools in this setting?
11.00-11.20 20mins	TB in HIV positive people: Ruling out TB & diagnosing TB & MDRTB	Helen Ayles Zambia/London	Difficulty diagnosing TB in HIV positive people. Difficulty obtaining specimens in HIV positive people Difficulty ruling-out TB to allow HAART Inadequacy of clinical algorithms Importance as barrier to preventive therapy Mortality from empiric regimes for HIV-MDRTB co-infection- Choices? Algorithms? Management?- extrapulmonary
11.20-11.35 15mins	The challenge of diagnosing paediatric TB	Heather Zar UCT	Choice, challenges, algorithms, PPD... Difficulty diagnosing & obtaining specimens Include sputum collection & induced sputum, fineneedle aspiration, gastric aspiration, stool, string etc. Maybe include IGRAs & urine tests Problems with lack of gold standard
11.35-11.50 15mins	Diagnostic biosafety : What’s required for what tests?	Paul Jensen CDC	How to protect lab staff; what is needed, what is realistic, what is enough... Challenge of taking diagnosis closer to the patient. Infecting staff; cross-contamination between tests Need for biosafety cabinet & autoclaves
11.50-12.10 10mins	Prize talk	Dirk Mueller LSHTM	"Estimating the resource need for using culture to diagnose TB"
12.10-12.40 30mins	Questions & Discussion	7-person panel of all of the above
12.40-2.00 80mins	Lunch and poster viewing