Chagas is not as well known as diseases such as malaria or cholera, but it affects between six and seven million people and kills up to 12,500 people each year.

In 2012, MSF treated 1,440 people for Chagas disease.

Chagas is a parasitic disease found almost exclusively on the American continent, though with increases in global travel cases have begun to be reported in the US and Europe.

Millions of people with the disease, including those infected decades ago, go undetected and untreated. Without treatment, Chagas can eventually progress to fatally damaging the heart, and the nervous and digestive systems.

MSF has treated patients with Chagas disease since 1999 and has worked in Bolivia, Guatemala, Honduras, Mexico, Brazil and Nicaragua. However, existing drugs and diagnostic tests are inadequate, expensive, and in short supply.

Without significant funding, MSF Chagas programs in Latin America have an uncertain future.

What Causes Chagas?

Chagas, or Trypanosoma cruzi, is a parasitic disease transmitted by an insect that lives in the walls and roofs of mud and straw housing, common in rural areas and urban slums in Latin America.

The bugs that carry the disease, known as ‘triatomines’, emerge at night to feed. Chagas has also been known to be transmitted through blood transfusions, organ transplants, breastfeeding and congenitally through a pregnant mother to her baby.

Contracting the disease through eating or drinking infected food or water is highly unusual but it has been recorded.

Facts

Chagas is transmitted by an insect called triatomines.
The chronic form of Chagas can damage the heart, oesophagus and colon.
Prevention is more effective than treatment.
MSF calls for better diagnostic tests and treatment for Chagas.

Symptoms of Chagas

Chagas disease has two stages: an acute stage, shortly after infection, and a chronic stage, developing over many years. Detecting Chagas in both stages is particularly difficult.

In the acute stage - the first few weeks after infection - only mild symptoms appear and they are common symptoms of many other diseases. These can range from body aches and fatigue to fever and vomiting.

After the acute phase, Chagas goes into remission and no other symptoms may appear for many years.

About 20 to 30 percent of those infected will go on to develop the chronic form of the disease where life-threatening heart and/or digestive disorders will develop, causing irreversible damage to the heart, esophagus, and colon. Symptoms at this stage might include constipation, digestive problems, abdominal pain and swallowing difficulties.

Diagnosing Chagas

MSF staff test a mother and child for Chagas disease. Bolivia, 2006.

MSF staff test a mother and child for Chagas disease. Bolivia, 2006. © Juan Carlos Tomasi

Diagnosing the disease is complicated. Doctors need to perform two or three blood tests to determine whether the patient is infected with the parasite and often these tests are inadequate, expensive, and in short supply.

MSF has called for the development of new diagnostic tests.

Treating Chagas

Treatment must occur in the acute stage of the infection, and because people who have been treated can easily be re-infected, treatment is more effective in areas with active vector control (the vector in this case being the insect that transmits the disease). To date, drugs have only been effective in the acute and asymptomatic stage of the disease.

There are few drugs that can effectively treat the disease and the current line of treatment can be toxic, taking one to two months to complete. Just like diagnostic tests for Chagas, treatments for the disease are also inadequate and expensive.

In Bolivia and Guatemala, MSF’s most effective Chagas programs have focused on preventative measures, education and screening in children.

In 2012, MSF treated 1,440 people for Chagas disease.


The MSF Access Campaign works to improve access to medicines and stimulate the development of urgently needed treatments. MSF Access Campaign.

 

An archive of MSF's scientific articles available free, with full text and in an easily searchable format. MSF Field Research website.

 

In 2003, seven organizations from around the world joined forces to establish DNDi, Drugs for Neglected Diseases Initiative.

 

This page was last updated on 2nd May 2013

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