Chagas: MSF Latest Updates
- MSF Statement on KaloBios Plan to Raise Price Of Drug To Treat Chagas Disease
- International Chagas Day: MSF begins work in Monteagudo in Chuquisaca, Bolivia
- Unsafe Passage: Treating Vulnerable Migrants in Mexico
- Care for Neglected Chagas Disease Now Available in Oaxaca State, Mexico
Chagas is a parasitic disease found almost exclusively on the American continent, though with increases in global travel cases have begun to be reported in the U.S. and Europe.
Millions of people with the disease, including those infected decades ago, go undetected and untreated. Without treatment, Chagas can eventually progress to fatally damaging the heart, and the nervous and digestive systems.
Doctors Without Borders/Médecins Sans Frontières (MSF) has treated patients with Chagas disease since 1999 and has worked in Bolivia, Guatemala, Honduras, Mexico, Brazil, and Nicaragua. However, existing drugs and diagnostic tests are inadequate, expensive, and in short supply.
Without significant funding, MSF Chagas programs in Latin America have an uncertain future.
What Causes Chagas?
Chagas, or Trypanosoma cruzi, is a parasitic disease transmitted by an insect that lives in the walls and roofs of mud and straw housing, common in rural areas and urban slums in Latin America.
The bugs that carry the disease, known as ‘triatomines’, emerge at night to feed. Chagas has also been known to be transmitted through blood transfusions, organ transplants, breastfeeding, and congenitally through a pregnant mother to her baby.
Contracting the disease through eating or drinking infected food or water is highly unusual but it has been recorded.
Symptoms of Chagas
Chagas disease has two stages: an acute stage, shortly after infection, and a chronic stage, developing over many years. Detecting Chagas in both stages is particularly difficult.
In the acute stage—the first few weeks after infection—only mild symptoms appear and they are common symptoms of many other diseases. These can range from body aches and fatigue to fever and vomiting.
After the acute phase, Chagas goes into remission and no other symptoms may appear for many years.
About 20 to 30 percent of those infected will go on to develop the chronic form of the disease where life-threatening heart and/or digestive disorders will develop, causing irreversible damage to the heart, esophagus, and colon. Symptoms at this stage might include constipation, digestive problems, abdominal pain, and swallowing difficulties.
Diagnosing the disease is complicated. Doctors need to perform two or three blood tests to determine whether the patient is infected with the parasite and often these tests are inadequate, expensive, and in short supply.
MSF has called for the development of new diagnostic tests.
Treatment must occur in the acute stage of the infection, and because people who have been treated can easily be re-infected, treatment is more effective in areas with active vector control (the vector in this case being the insect that transmits the disease). To date, drugs have only been effective in the acute and asymptomatic stage of the disease.
There are few drugs that can effectively treat the disease and the current line of treatment can be toxic, taking one to two months to complete. Just like diagnostic tests for Chagas, treatments for the disease are also inadequate and expensive.
Chagas in Bolivia
The following excerpt is adapted from the 2014 MSF Activity Report
As many as one million people are estimated to be infected with Chagas disease in Bolivia. Chagas is endemic across 60 percent of Bolivia and is commonly transmitted by the vinchuca bug (Triatoma infestans), which lives in the cracks and roofs of rural adobe houses. Only four percent of those people infected get treatment, owing to a lack of access to care.
The government recognizes this as a major health issue and has been working to address it; however, Chagas treatment is not guaranteed or integrated into basic health care. MSF has set up Chagas treatment programs over the years it has been working in Bolivia, particularly in Narciso Campero province in Cochabamba department, where the disease is especially prevalent. The health ministry has managed that program since 2013.
In 2014, MSF teams focused on another priority area: Chuquisaca department, Monteagudo municipality, in Hernando Siles province. Hardly any of the 61,900 residents of this region have access to treatment. In partnership with the health ministry, MSF is working on a model of prevention and treatment to be integrated into the basic healthcare system.
MSF also collaborated with the health ministry in partnership with Johns Hopkins University this year to prepare the launch of EMOCHA, an e-mobile surveillance application. upon detection of a vinchuca infestation, a community volunteer will send a free SMS to a central information system, and a vector control team will be deployed.
The MSF Access Campaign works to improve access to medicines and stimulate the development of urgently needed treatments. MSF Access Campaign.
An archive of MSF's scientific articles available free, with full text and in an easily searchable format. MSF Field Research website.
In 2003, seven organizations from around the world joined forces to establish DNDi, Drugs for Neglected Diseases Initiative.
This page was last updated on September 28, 2015