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Medical Research

Medical data and research from Doctors Without Borders/Médecins Sans Frontières (MSF) field operations are regularly published in the peer-reviewed literature.

Below is a selection of recently published MSF medical research articles. For copies or to search all MSF research publications, please visit the MSF Field Research website, or contact Dr. Patricia Kahn, Medical Editor, patricia.kahn[at]newyork.msf.org.

MSF research articles on Neglected Diseases

August 11, 2010

Challenges in mass drug administration for treating lymphatic filariasis in Papua, Indonesia

Navneet Bhullar, Jacob Maikere
Parasites and Vectors 2010;3:70. (doi: 10.1186/1756-3305-3-70)

Filariasis, Indonesia, Neglected Diseases

November 1, 2009

Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras

Josep M Escribà, Elisa Ponce, Alberto de Dios Romero, Pedro Albajar Viñas, Andrea Marchiol, Glòria Bassets, Pedro Pablo Palma, M Angeles Lima, Concepción Zúniga, Carlos Ponce
Mem Inst Oswaldo Cruz 2009;104(7):986-91.
Memórias do Instituto Oswaldo Cruz

Chagas Disease, Honduras, Neglected Diseases

September 1, 2009

Natural history of a visceral leishmaniasis outbreak in highland Ethiopia

Mercè Herrero, Giannos Orfanos, Daniel Argaw, Abate Mulugeta, Pilar Aparicio, Fernando Parreño, Oscar Bernal, Daniel Rubens, Jaime Pedraza, Maria Angeles Lima, Laurence Flevaud, Pedro Pablo Palma, Seife Bashaye, Jorge Alvar, Caryn Bern
Am J Trop Med Hyg 2009;81:373-7.
American Journal of Tropical Medicine and Hygiene

Ethiopia, Kala Azar, Neglected Diseases

July 7, 2009

Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières

Oliver Yun, M. Angeles Lima, Tom Ellman, Wilma Chambi, Sandra Castillo, Laurence Flevaud, Paul Roddy, Fernando Parreño, Pedro Albajar Viñas, Pedro Pablo Palma
PLoS Negl Trop Dis 2009;3(7):e488.
PLoS Neglected Tropical Diseases

Bolivia, Chagas Disease, Guatemala, Honduras, Neglected Diseases

June 24, 2009

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: A multicentre, randomised, phase III, non-inferiority trial

Gerardo Priotto, Serena Kasparian, Wilfried Mutombo, Daniel Ngouama, Sara Ghorashian, Ute Arnold, Salah Ghabri, Elisabeth Baudin, Vincent Buard, Serge Kazadi-Kyanza, Médard Ilunga, Willy Mutangala, Gabriele Pohlig, Caecilia Schmid, Unni Karunakara, Els Torreele, Victor Kande
Lancet 2009;374:56-64

Congo, Democratic Republic of the Congo, Neglected Diseases, Sleeping Sickness

June 23, 2009

Prevalence of buruli ulcer in Akonolinga health district, Cameroon: Results of a cross sectional survey

Klaudia Porten, Karen Sailor, Eric Comte, Adelaide Njikap, Agnes Sobry, Francois Sihom, Abanda Meva'a, Sarah Eyangoh, Mark Myatt, Fabienne Nackers, Rebecca F. Grais
PLoS Neglected Tropical Diseases 2009;3:e466. (doi: 10.1371/journal.pntd.0000466)

Buruli Ulcer, Cameroon, Neglected Diseases

June 22, 2009

Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda

Yolanda Mueller, Dawson B. Mbulamberi, Peter Odermatt, Axel Hoffmann, Louis Loutan, François Chappuis
Trop Med Int Health 2009;14:910-7.
Tropical Medicine & International Health

Kala Azar, Neglected Diseases, Uganda

February 18, 2009

Risk factors for Buruli ulcer in Côte d’Ivoire: results of a case-control study, August 2001

Laurence Ahoua, Aka N. Guetta, Euloge Ekaza, Samir Bouzid, Raymond N’Guessan, Mireille Dosso
African Journal of Biotechnology 2009;8(4):536-46.

Buruli Ulcer, Ivory Coast, Neglected Diseases

October 22, 2008

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes

Manica Balasegaram, Heather Young, François Chappuis, Gerardo Priotto, Marie-Eve Raguenaud, Francesco Checchi
Transactions of the Royal Society of Tropical Medicine and Hygiene 2009;103:280-290. (doi: 10.1016/j.trstmh.2008.09.005)

Neglected Diseases, Sleeping Sickness

June 1, 2008

International meeting: New diagnostic tests are urgently needed to treat patients with Chagas disease

Campaign for Access to Essential Medicines, Médecins Sans Frontières
Rev Soc Bras Med Trop 2008;41(3):315-9.
Revista da Sociedade Brasileira de Medicina Tropical

Chagas Disease, Diagnostics, Neglected Diseases

April 17, 2008

Concordant HIV infection and visceral leishmaniasis in Ethiopia: The influence of antiretroviral treatment and other factors on outcome

Rachel ter Horst, Simon M. Collin, Koert Ritmeijer, Adey Bogale, Robert N. Davidson
Clinical Infectious Diseases 2008;46:1702-1709. (doi: 10.1086/587899)

Ethiopia, HIV/AIDS, Kala Azar, Neglected Diseases

April 9, 2008

Field evaluation of a rapid immunochromatographic assay for Trypanosoma cruzi infection using whole blood in Sucre, Bolivia

Paul Roddy, Javier Goiri, Laurence Flevaud, Pedro Pablo Palma, Silvia Morote, Nines Lima, Luis Villa, Faustino Torrico, Pedro Albajar-Viñas
J Clin Microbiol 2008;46(6):2022-7.
Journal of Clinical Microbiology

Bolivia, Chagas Disease, Neglected Diseases

March 5, 2008

Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: Cohort study

Gerardo Priotto, Loretxu Pinoges, Isaac Badi Fursa, Barbara Burke, Nathalie Nicolay, Guillaume Grillet, Cathy Hewison, Manica Balasegaram
BMJ 2008;336:705-708. (doi: 10.1136/bmj.39485.592674.BE)

Neglected Diseases, Sleeping Sickness, Sudan

February 8, 2008

Estimates of the duration of the early and late stage of gambiense sleeping sickness

Francesco Checchi, Joao A.N. Filipe, Daniel T. Haydon, Daniel Chandramohan, Francois Chappuis
BMC Infectious Diseases 2008;8:16. (doi: 10.1186/1471-2334-8-16)

Neglected Diseases, Sleeping Sickness, Sudan, Uganda

February 1, 2008

Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola

J Robays, ME Raguenaud, T Josenando, M Boelaert
Tropical Medicine & International Health 2008;13:265-271. (doi: 10.1111/j.1365-3156.2007.01999.x)

Angola, Neglected Diseases, Sleeping Sickness

January 9, 2008

Risk factors of visceral leishmaniasis in East Africa: A case-control study in Pokot territory of Kenya and Uganda

Jan H Kolaczinski, Richard Reithinger, Dagemlidet T Worku, Andrew Ocheng, John Kasimiro, Narcis Kabatereine, Simon Brooker
International Journal of Epidemiology 2008;37:344-352. (doi: 10.1093/ije/dym275)

Kala Azar, Kenya, Neglected Diseases, Uganda

January 1, 2008

Safety and effectiveness of amphotericin B deoxycholate for the treatment of visceral leishmaniasis in Uganda

Y Mueller, A Nguimfack, P Cavailler, S Couffignal, JB Rwakimari, L Loutan, F Chappuis
Annals of Tropical Medicine and Parasitology 2008;102:11-19. (doi: 10.1179/136485908X252142)

Kala Azar, Neglected Diseases, Uganda

November 7, 2007

Nifurtimox plus eflornithine for late-stage sleeping sickness in Uganda: A case series

Francesco Checchi, Patrice Piola, Harriet Ayikoru, Florence Thomas, Dominique Legros, Gerardo Priotto
PLoS Neglected Tropical Diseases 2007;1:e64. (doi: 10.1371/journal.pntd.0000064)

Neglected Diseases, Sleeping Sickness, Uganda

October 31, 2007

Epidemiology and clinical features of patients with visceral leishmaniasis treated by an MSF clinic in Bakool Region, Somalia, 2004–2006

Marie-Eve Raguenaud et al.
PLoS Neglected Tropical Diseases 2007;1:e85. (doi: 10.1371/journal.pntd.0000085)

Kala Azar, Neglected Diseases, Somalia

July 1, 2007

Treatment of kala-azar in southern Sudan using a 17-day regimen of sodium stibogluconate combined with paromomycin: A retrospective comparison with 30-day sodium stibogluconate monotherapy

Yosef Melaku, Simon M. Collin, Kees Keus, Francis Gatluak, Koert Ritmeijer, Robert N. Davidson
American Journal of Tropical Medicine and Hygiene 2007;77:89-94.

Kala Azar, Neglected Diseases, Sudan

April 1, 2007

Utility of lymph node aspiration in the diagnosis of visceral leishmaniasis in Sudan

Zahir O. Babiker, Robert Davidson, Charles Mazinda, Sammy Kipngetich, Koert Ritmeijer
American Journal of Tropical Medicine and Hygiene 2007;76:689-693.

Kala Azar, Neglected Diseases, Sudan

March 1, 2007

Kala-azar control, Uganda [letter]

Jan H. Kolaczinski, Dagemlidet Tesfaye Worku, François Chappuis, Richard Reithinger, Narcis Kabatereine, Ambrose Onapa, Simon Brooker
Emerging Infectious Diseases 2007;13:507-509.

Kala Azar, Neglected Diseases, Uganda

March 1, 2007

Evaluation of a mass distribution programme for fine-mesh impregnated bednets against visceral leishmaniasis in eastern Sudan

Koert Ritmeijer, Clive Davies, Ruth van Zorge, Shr-Jie Wang, Judy Schorscher, Salah Ibrahim Dongu'du, Robert N. Davidson
Tropical Medicine & International Health 2007;12:404-414.

Kala Azar, Neglected Diseases, Sudan

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