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Medical Research

Medical data and research from Doctors Without Borders/Médecins Sans Frontières (MSF) field operations are regularly published in the peer-reviewed literature.

Below is a selection of recently published MSF medical research articles. For copies or to search all MSF research publications, please visit the MSF Field Research website, or contact Dr. Patricia Kahn, Medical Editor, patricia.kahn[at]newyork.msf.org.

MSF research articles on Malaria

October 6, 2010

Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial

Patrice Piola, Carolyn Nabasumba, Eleanor Turyakira, Mehul Dhorda, Niklas Lindegardh, Dan Nyehangane, Georges Snounou, Elizabeth A Ashley, Rose McGready, Francois Nosten, Philippe J Guerin
Lancet Infectious Diseases 2010;10(11):762-9. (doi: 10.1016/S1473-3099(10)70202-4)

Malaria, Uganda

September 9, 2010

Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial

Frank Smithuis, Moe Kyaw Kyaw, Ohn Phe, Thein Win, Pyay Phyo Aung, Aung Pyay Phyo Oo, Arkar Linn Naing, Mya Yee Nyo, Naing Zaw Htun Myint, Mallika Imwong, Elizabeth Ashley, Sue J Lee, Nicholas J White
Lancet Infectious Diseases 2010;10(10):673-81. (doi: 10.1016/S1473-3099(10)70187-0)

Malaria, Myanmar

January 26, 2010

Microscopy quality control in Médecins Sans Frontières programs in resource-limited settings

Derryck B Klarkowski, Juan Daniel Orozco
PLoS Medicine 2010;7(1):e1000206. (doi: 10.1371/journal.pmed.1000206)

Diagnostics, Malaria, Tuberculosis

January 21, 2010

Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone

Sibylle Gerstl, Sophie Dunkley, Ahmed Mukhtar, Martin De Smet, Samuel Baker, Jacob Maikere
Malaria Journal 2010;9(1):28. (doi: 10.1186/1475-2875-9-28)

Diagnostics, Malaria, Sierra Leone

January 19, 2010

In vivo parasitological measures of artemisinin susceptibility

Kasia Stepniewska, Sue J Lee, Nicholas Anstey, Karen I Barnes, Tran Quang Binh, Umberto D’Alessandro, Nicholas PJ Day, Peter J de Vries, Grant Dorsey, Jean-Paul Guthmann, Mayfong Mayxay, Paul N Newton, Piero Olliaro, Lyda Osorio, Ric N Price, Mark Rowland, Frank Smithuis, Walter RJ Taylor, François Nosten, Nicholas J White
Journal of Infectious Diseases 2010;201(4):570-9. (doi: 10.1016/j.inhe.2009.12.008)

Malaria

July 29, 2009

Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: A prospective multi-centre individual patient data analysis

Julien Zwang, Elizabeth A. Ashley, Corine Karema, Umberto D'Alessandro, Frank Smithuis, Grant Dorsey, Bart Janssens, Mayfong Mayxay, Paul Newton, Pratap Singhasivanon, Kasia Stepniewska, Nicholas J. White, François Nosten
PLoS ONE 2009;4:e6358. (doi: 10.1371/journal.pone.0006358)

Malaria

August 5, 2008

Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: The role of Médecins Sans Frontières

Jean-Paul Guthmann, Francesco Checchi, Ingrid van den Broek, Suna Balkan, Michel van Herp, Eric Comte, Oscar Bernal, Jean-Marie Kindermans, Sarah Venis, Dominique Legros, Philippe J. Guerin
PLoS Medicine 2008;5:e169. (doi: 10.1371/journal.pmed.0050169)

Malaria

January 7, 2008

Population pharmacokinetics of piperaquine after two different treatment regimens of dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand

J Tarning, EA Ashley, N Lindegardh, K Stepniewska, L Phaiphun, NPJ Day, R McGready, M Ashton, F Nosten, NJ White
Antimicrobial Agents and Chemotherapy 2008;52:1052-1061. (doi: 10.1128/AAC.00955-07)

Malaria, Myanmar, Thailand

January 1, 2008

Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar

Jean-Paul Guthmann, Anne Pittet, Alexandre Lesage, Mallika Imwong, Niklas Lindegardh, Myo Min Lwin, Than Zaw, Anna Annerberg, Xavier de Radiguès, François Nosten
Tropical Medicine & International Health 2008;13:91-98. (doi: 10.1111/j.1365-3156.2007.01978.x)

Malaria, Myanmar

January 1, 2008

Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment

Piero Olliaro, Loretxu Pinoges, Francesco Checchi, Michel Vaillant, Jean-Paul Guthmann
Tropical Medicine & International Health 2008;13:83-90. (doi: 10.1111/j.1365-3156.2007.01977.x)

Malaria

November 26, 2007

Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria

Carole Fogg, Rogers Twesigye, Vincent Batwala, Patrice Piola, Carolyn Nabasumba, James Kiguli, Frederick Mutebi, Christa Hook, Martine Guillerm, Anthony Moody, Jean-Paul Guthmann
Transactions of the Royal Society of Tropical Medicine and Hygiene 2008;102:25-31. (doi: 10.1016/j.trstmh.2007.09.014)

Malaria, Uganda

September 24, 2007

Forecasting malaria incidence based on monthly case reports and environmental factors in Karuzi, Burundi, 1997-2003

Alberto Gomez-Elipe, Angel Otero, Michel van Herp, Armando Aguirre-Jaime
Malaria Journal 2007;6:129. (doi: 10.1186/1475-2875-6-129)

Burundi, Malaria

July 18, 2007

Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction

Sibylle Gerstl, Sandra Cohuet, Kodjo Edoh, Christopher Brasher, Alexandre Lesage, Jean-Paul Guthmann, Francesco Checchi
Malaria Journal 2007;6:94. (doi: 10.1186/1475-2875-6-94)

Access to Medicines, Burundi, Malaria

July 16, 2007

Vector control in a malaria epidemic occurring within a complex emergency situation in Burundi: A case study

Natacha Protopopoff, Michel Van Herp, Peter Maes, Tony Reid, Dismas Baza, et al.
Malaria Journal 2007;6:93. (doi: 10.1186/1475-2875-6-93)

Burundi, Malaria, Vaccination Campaign

May 16, 2007

Paracheck-Pf® accuracy and recently treated Plasmodium falciparum infections: Is there a risk of over-diagnosis?

Todd D Swarthout, Helen Counihan, Raphael Kabangwa K Senga, Ingrid van den Broek
Malaria Journal 2007;6:58. (doi: 10.1186/1475-2875-6-58)

Democratic Republic of the Congo, Malaria

May 3, 2007

Efficacy of antimalarial treatment in Guinea: In vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine-pyrimethamine in N'Zérékoré

Maryline Bonnet, Cally Roper, Martine Félix, Léonie Coulibaly, Gabriel Mufuta Kankolongo, Jean Paul Guthmann
Malaria Journal 2007;6:54. (doi: 10.1186/1475-2875-6-54)

Access to Medicines, Guinea, Malaria

February 1, 2007

Mosquitoborne infections after Hurricane Jeanne, Haiti, 2004

Mark E. Beatty et al.
Emerging Infectious Diseases 2007;13:308-310.

Haiti, Malaria, Natural Disaster

February 1, 2007

A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia

B Janssens, M van Herp, L Goubert, S Chan, S Uong, S Nong, D Socheat, A Brockman, EA Ashley, W Van Damme
Tropical Medicine & International Health 2007;12:251-259.

Cambodia, Malaria

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