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Medical Research

Medical data and research from Doctors Without Borders/Médecins Sans Frontières (MSF) field operations are regularly published in the peer-reviewed literature.

Below is a selection of recently published MSF medical research articles. For copies or to search all MSF research publications, please visit the MSF Field Research website, or contact Dr. Patricia Kahn, Medical Editor, patricia.kahn[at]newyork.msf.org.

MSF research articles on Tuberculosis

April 19, 2011

Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study

Catharina C Boehme, Mark P Nicol, Pamela Nabeta, Joy S Michael, Eduardo Gotuzzo, Rasim Tahirli, Ma Tarcela Gler, Robert Blakemore, William Worodria, Christen Gray, Laurence Huang, Tatiana Caceres, Rafail Mehdiyev, Lawrence Raymond, Andrew Whitelaw, Kalaiselvan Sagadevan, Heather Alexander, Heidi Albert, Frank Cobelens, Helen Cox, David Alland, Mark D Perkins
Lancet 2011;377:1495-505

Diagnostics, South Africa, Tuberculosis

December 1, 2010

Tuberculosis treatment in a refugee and migrant population: 20 years of experience on the Thai-Burmese border

Minetti A, Camelique O, Hsa Thaw K, Thi S, Swaddiwudhipong W, Hewison C, Pinoges L, Bonnet M, Guerin PJ
Int J Tuberc Lung Dis 2010;14(12):1589-95
International Journal of Tuberculosis and Lung Disease

Myanmar, Thailand, Tuberculosis

October 25, 2010

New diagnostics for tuberculosis: fulfilling patient needs first

Jean-Francois Lemaire, Martina Casenghi
J Int AIDS Soc 2010;13:40
Journal of the International AIDS Society

Access to Medicines, Diagnostics, Tuberculosis

April 9, 2010

Impact of introducing human immunodeficiency virus testing, treatment and care in a tuberculosis clinic in rural Kenya

H Huerga, H Spillane, W Guerrero, A Odongo, F Varaine
International Journal of Tuberculosis and Lung Disease 2010;14(5):611-5.

HIV/AIDS, HIV/TB Co-infection, Kenya, Tuberculosis

January 26, 2010

Microscopy quality control in Médecins Sans Frontières programs in resource-limited settings

Derryck B Klarkowski, Juan Daniel Orozco
PLoS Medicine 2010;7(1):e1000206. (doi: 10.1371/journal.pmed.1000206)

Diagnostics, Malaria, Tuberculosis

November 23, 2009

Outcomes after chemotherapy with WHO category II regimen in a population with high prevalence of drug resistant tuberculosis

Francine Matthys, Leen Rigouts, Vinciane Sizaire, Natalia Vezhnina, Maryvonne Lecoq, Vera Golubeva, Françoise Portaels, Patrick Van der Stuyft, Michael Kimerling
PLoS ONE 2009;4(11):e7954. (doi: 10.1371/journal.pone.0007954)

Russian Federation, Tuberculosis

September 1, 2009

Evaluation of FASTPlaqueTB to diagnose smear-negative tuberculosis in a peripheral clinic in Kenya

M Bonnet, L Gagnidze, F Varaine, A Ramsay, W Githui, PJ Guerin
International Journal of Tuberculosis and Lung Disease 2009;13:1112-8.

Diagnostics, Kenya, Tuberculosis

July 17, 2009

An integrated approach of community health worker support for HIV/AIDS and TB care in Angónia district, Mozambique

Sandrine Simon, Kathryn Chu, Marthe Frieden, Baltazar Candrinho, Nathan Ford, Helen Schneider, Marc Biot
BMC International Health and Human Rights 2009;9:13. (doi: 10.1186/1472-698X-9-13)

HIV/AIDS, Mozambique, Tuberculosis

June 18, 2009

Characteristics of drug-resistant tuberculosis in Abkhazia (Georgia), a high-prevalence area in Eastern Europe

Manuela Pardinia, Stefan Niemann, Francis Varaine, Elisabetta Iona, Francesca Meacci, Germano Orrù, Hasan Yesilkaya, Thierry Jarosz, Peter Andrew, Mike Barer, Francesco Checchi, Heinz Rinder, Graziella Orefici, Sabine Rüsch-Gerdes, Lanfranco Fattorini, Marco Rinaldo Oggioni, Maryline Bonnet
Tuberculosis 2009;89(4):317-24. (doi: 10.1016/j.tube.2009.04.002)

Georgia, Tuberculosis

June 10, 2008

Adapting the DOTS framework for tuberculosis control to the management of non-communicable diseases in sub-Saharan Africa

Anthony D. Harries, Andreas Jahn, Rony Zachariah, Donald Enarson
PLoS Medicine 2008;5:e124. (doi: 10.1371/journal.pmed.0050124)

Tuberculosis

June 1, 2008

Bleach sedimentation: An opportunity to optimize smear microscopy for tuberculosis diagnosis in settings of high prevalence of HIV

Maryline Bonnet, Andrew Ramsay, Willie Githui, Laramie Gagnidze, Francis Varaine, Philippe J. Guerin
Clinical Infectious Diseases 2008;46:1710-1716. (doi: 10.1086/587891)

Kenya, Tuberculosis

December 19, 2007

Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis

Karen Cohen, Gilles van Cutsem, Andrew Boulle, Helen McIlleron, Eric Goemaere, Peter J. Smith, Gary Maartens
Journal of Antimicrobial Chemotherapy 2008;61:389-393. (doi: 10.1093/jac/dkm484)

HIV/AIDS, South Africa, Tuberculosis

November 7, 2007

Multidrug-resistant tuberculosis treatment outcomes in Karakalpakstan, Uzbekistan: Treatment complexity and XDR-TB among treatment failures

Helen S. Cox, Stobdan Kalon, Sholpan Allamuratova, Vinciane Sizaire, Zinaida N. Tigay, Sabine Rüsch-Gerdes, Hamraev A. Karimovich, Yared Kebede, Clair Mills
PLoS ONE 2007;2:e1126. (doi: 10.1371/journal.pone.0001126)

Tuberculosis, Uzbekistan

November 6, 2007

Randomized trials to optimize treatment of multidrug-resistant tuberculosis: The time for action is now

Carole D. Mitnick, Kenneth G. Castro, Mark Harrington, Leonard V. Sacks, William Burman
PLoS Medicine 2007;4:e292. (doi: 10.1371/journal.pmed.0040292)

Access to Medicines, Tuberculosis

November 6, 2007

Building clinical trials capacity for tuberculosis drugs in high-burden countries

Neil Schluger, Unni Karunakara, Christian Lienhardt, Thomas Nyirenda, Richard Chaisson
PLoS Medicine 2007;4:e302. (doi: 10.1371/journal.pmed.0040302)

Access to Medicines, Tuberculosis

November 6, 2007

New approaches to filling the gap in tuberculosis drug discovery

Martina Casenghi, Stewart T. Cole, Carl F. Nathan
PLoS Medicine 2007;4:e293. (doi: 10.1371/journal.pmed.0040293)

Access to Medicines, Tuberculosis

October 1, 2007

Population differences in death rates in HIV-positive patients with tuberculosis

I Ciglenecki, JR Glynn, A Mwinga, B Ngwira, A Zumla, PEM Fine, A Nunn
International Journal of Tuberculosis and Lung Disease 2007;11:1121-1128.

HIV/AIDS, Malawi, Tuberculosis, Vaccination Campaign, Zambia

September 1, 2007

Reducing the number of sputum samples examined and thresholds for positivity: An opportunity to optimise smear microscopy

M Bonnet, A Ramsay, L Gagnidze, W Githui, PJ Guerin, F Varaine
International Journal of Tuberculosis and Lung Disease 2007;11:953-958.

Kenya, Tuberculosis

August 1, 2007

Does antiretroviral treatment reduce case fatality among HIV-positive patients with tuberculosis in Malawi?

R Zachariah, M Fitzgerald, M Massaquoi, A Acabu, D Chilomo, FM Salaniponi, AD Harries
International Journal of Tuberculosis and Lung Disease 2007;11:848-853.

HIV/AIDS, Malawi, Tuberculosis

July 1, 2007

Evaluation of a diagnostic algorithm for smear-negative pulmonary tuberculosis in HIV-infected adults

P Saranchuk, A Boulle, K Hilderbrand, D Coetzee, M Bedelu, G van Cutsem, G Meintjes
South African Medical Journal 2007;97:517-523.

HIV/AIDS, South Africa, Tuberculosis

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